TOFA molecule reduces body weight in mice by 18% without appetite suppression

TOFA molecule reduces body weight in mice by 18% without appetite suppression

The TOFA molecule, which targets fatty acid synthesis enzymes and nuclear receptors, reduced body weight in mice by approximately 18% over four weeks. The weight loss occurred in adipose tissue while muscle mass was preserved. These results were obtained exclusively in animal experiments; additional preclinical and clinical trials are required before human use. Mechanism of Action TOFA inhibits acetyl-CoA carboxylases ACC1 and ACC2, enzymes involved in the synthesis of fatty acids. Simultaneousl