- Sickle cell disease affects 7.7M globally, mostly sub-Saharan Africa (300K+ births/year).
- Red blood cell exchange (RBCX) replaces sickled cells with healthy ones, reducing pain, strokes, organ damage.
- Proven at AMCE Nigeria using Terumo Optia; patient pain-free post-procedure.
- Alternative to donor-limited bone marrow transplants: repeatable, accessible.
- Also treats malaria parasitaemia, CO poisoning; expands African care options.